Phenytoin clearance
Web1. máj 2006 · Drug. Effect of phenytoin on drug. Theophylline. Clearance increased by 45%. Carbamazepine. Increased metabolism; decrease in plasma concentration to subtherapeutic range; carbamazepine may also decrease concentration of phenytoin; monitor concentrations of both drugs. Ethosuximide. Increased metabolism, higher oral clearance, … Web19. nov 2010 · In a small pharmacokinetic study, phenytoin clearance was reduced by 30% when combined with TMP [12]. Given the saturable nature of phenytoin metabolism, decreases in phenytoin clearance of this magnitude may lead to clinically significant increases in phenytoin concentrations.
Phenytoin clearance
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Web17. okt 1977 · It is important to remember that since phenytoin’s elimination is a saturable process, and clearance decreases with increasing concentrations, the steady state concentration is NOT proportional to the … Web24. feb 2024 · Phenytoin clearance is decreased in elderly patients and lower or less frequent dosing may be required (see section 5.2 Pharmacokinetic properties-Age). As …
Web28. mar 2024 · Age: Phenytoin clearance tends to decrease with increasing age (20% less in patients over 70 years of age relative to that in patients 20-30 years of age). Phenytoin … Web1. jan 2024 · Altered phenytoin clearance during intensive chemotherapy for acute lymphoblastic leukemia. J Pediatr. 1988;112:996–9. CrossRef CAS PubMed Google Scholar Boruban MC, Yasar U, Babaoglu MO, Sencan O, Bozkurt A. Tamoxifen inhibits cytochrome P450 2C9 activity in breast cancer patients.
Web1. dec 2024 · Phenytoin clearance is decreased slightly in elderly patients and lower or less frequent dosing may be required [see Clinical Pharmacology (12.3)]. Dosing during Pregnancy Decreased serum concentrations of phenytoin may occur during pregnancy because of altered phenytoin pharmacokinetics. Web4. sep 2024 · After IV fosphenytoin sodium administration to patients with hepatic impairment, fosphenytoin conversion to phenytoin may be increased without an …
WebPhenytoin is used in the management of generalized tonico-clonic and complex partial seizures. It may also be used in the prevention of seizures following head trauma, and in …
WebAt steady-state, enzyme induction will increase the rate of clearance of phenytoin such that the dose must be increased approximately 30% to maintain therapeutic levels. Uremia has a similar effect on phenytoin protein binding. In uremia, by-products of normal metabolism accumulate and bind to albumin, displacing phenytoin, which causes an ... medicheck servicesWebThe present work was designed to evaluate the effect of some commonly used herbs viz. garden cress (Lepidium sativum), black seed (Nigella sativa) and fenugreek (Trigonella foenum-graceum) on the dis medichecks ironWeb1. júl 2008 · There was no difference between adult and elderly or men and women in PHT clearance, distribution volume, and elimination half-life. The mean elimination half-life was … nachthemd warm lang biberWebtitle = "Phenytoin half-life and clearance during maintenance therapy in adults and elderly patients with epilepsy", abstract = "Background: Phenytoin (PHT) is widely used to treat … medichecks folate testWebWhen aspirin displaces other drugs from protein-binding sites on serum albumin, it increases the unbound fraction, producing a toxic unbound concentration. This can affect the actions of drugs that are highly protein bound and have low volumes of … medichecks full blood countWeb1. apr 1994 · In a previous article (Article 1 - `Clearance' Aust Prescr 1988;11:12-3), it was shown that the steady state blood concentration (C ss) is a function of both the dose and … medichecks glasgowWebPreparations containing phenytoin sodium are not bioequivalent to those containing phenytoin base (such as Epanutin Infatabs® and Epanutin® suspension); 100 mg of … nach therefore ein komma