Cytoplasmic mucin
WebStains glycogen, mucin, fungus, basement membrane and other substances. Stain used to detect fungal organisms and cytoplasmic accumulation of glycogen. Stains glycogen … WebOct 7, 2010 · The cells lack a uniform, geometric distribution in the cluster and mucin fills the cytoplasmic compartment. The nuclei are round and regular with even chromatin and smooth nuclear membranes …
Cytoplasmic mucin
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WebMucinous carcinomas, defined as tumors in which at least 50% of the cells are mucinous, can occur in the endometrium and are similar to those that arise from the endocervix. … WebOct 6, 2024 · The tumor cells lined the alveolar walls or proliferated with a papillary pattern and consisted of columnar cells with abundant cytoplasmic mucin and basally oriented …
WebFeb 4, 2013 · Mucins are the key polymeric, viscoelastic and protective components of mucus. In addition to mucins, mucus is comprised of water, ions, and molecules of the … WebJun 11, 2024 · cytoplasm, and nuclear molding. Extensive necrosis. Tons of mitoses. Ki67 almost 100%. Large Cell Neuroendocrine Carcinoma Morphology: Large, round nuclei, …
WebJun 7, 2024 · Scattered tumor cells with cytoplasmic mucin were also present; however, ciliated cells and serous gland-like granules were absent. Tumor cells also proliferated within the tracheal epithelium adjacent to the polypoid lesion. Neither infiltration growth into the tracheal wall nor necrosis was observed (Fig. 1C–F). Immunohistochemical findings ... WebJan 1, 2024 · GI mucin-producing cells tend to have concentrated, apical mucin cups (foveolar epithelium or goblet cells) as opposed to the more diffuse, cytoplasmic mucin content of MCN. When separating MCN from other non-mucinous cysts, the quality and quantity of the cyst fluid is important.
WebAbstact. MUC1, a transmembrane mucin, is a key modulator of several signaling pathways that affect oncogenesis, motility, and cell morphology. The interaction of MUC1 cytoplasmic tail (MUC1CT) with signal transducers and its nuclear translocation and subsequent biological responses are believed to be regulated by phosphorylation status, but the …
Mucins are secreted as massive aggregates of proteins with molecular masses of roughly 1 to 10 million Da. Within these aggregates, monomers are linked to one another mostly by non- covalent interactions, although intermolecular disulfide bonds may also play a role in this process. Secretion [ edit] See more Mucins are a family of high molecular weight, heavily glycosylated proteins (glycoconjugates) produced by epithelial tissues in most animals. Mucins' key characteristic is their ability to form gels; therefore they are a … See more Human mucins include genes with the HUGO symbol MUC 1 through 22. Of these mucins, the following classes have been defined by … See more The functional classification does not correspond to an exact evolutionary relationship, which is still incomplete and ongoing. Known-related groups include: • The … See more Mucin genes encode mucin monomers that are synthesized as rod-shaped apomucin cores that are post-translationally modified by exceptionally abundant glycosylation. The dense "sugar coating" of mucins gives them considerable water-holding capacity and also makes … See more Mature mammalian mucins are composed of two distinct regions: • The amino- and carboxy-terminal regions are very lightly glycosylated, but rich in cysteines. … See more Mucins have been found to have important functions in defense against bacterial and fungal infections. MUC5B, the predominant mucin in the mouth and female genital tract, … See more Upon stimulation, MARCKS (myristylated alanine-rich C kinase substrate) protein coordinates the secretion of mucin from mucin-filled vesicles within the specialized epithelial cells. Fusion of the vesicles to the plasma membrane causes release of the mucin, which as … See more diary\u0027s r5WebThe MUC1 gene provides instructions for making a protein called mucin 1. This protein is one of several mucin proteins that make up mucus, a slippery substance that lubricates … diary\u0027s r4WebThe neoplastic cells have clear cytoplasm because they contain abundant intracytoplasmic glycogen. They do not produce mucin. ... Adenomas are considered to have simple mucinous columnar cells, low nucleus-to-cytoplasm ratio, apical cytoplasmic mucin, diffuse and fine chromatin pattern, and no cytological atypia. Borderline cases exhibit ... citigold applyWebThe mucin (MUC) family is a group of highly glycosylated macromolecules that are abundantly expressed in mammalian epithelial cells. MUC proteins contribute to the formation of the mucus barrier and thus have protective functions against infection. Interestingly, some MUC proteins are aberrantly expressed in cancer cells and are … diary\\u0027s r7WebThe MUC13 transmembrane mucin has a 69-amino-acid cytoplasmic tail that includes 5 potential serine phosphorylation sites 104. Overexpression of MUC13 has been found in gastrointestinal 105 , 106 ... citigold bankWebOct 31, 2024 · Other HFCs showed SRC differentiation, with nuclei pressed to one edge of the cell and distorted by cytoplasmic mucin that appeared as a single clear vacuole in HFCs and as a foamy, multivesicular cytoplasmic material in others (Figs. 7 and 8 ). There were no mitotic figures in the HFCs. citigold banking loginWebOct 15, 2024 · TFF2 and αGlcNAc-R were detected in the cytoplasmic mucin of mucous glands and luminal secretions (asterisk) and MUC6 was detected in the cytoplasm. AIS showing nuclear enlargement and irregularity and conspicuous nucleoli with a variable amount of apical mucin. TFF2 and αGlcNAc-R were detected in the cytoplasmic mucin … diary\u0027s r8