Cholyl-l-lysyl-fluorescein

Author: sbgj

August undefined, 2024

WebMethods: We analyzed biliary excretion kinetics of cholyl lysyl fluorescein (CLF), lithocholyl lysyl fluorescein (LLF) and sulfo-lithocholyl lysyl fluorescein (sLLF), both in the isolated rat hepatocyte couplet model and in TR- rats with a selective canalicular transport defect of non-bile acid organic anions. WebJul 1, 2010 · Abstract. Cholyl- l -lysyl-fluorescein (CLF) is a fluorescent bile salt derivative that is being developed as an agent for determining in vivo liver …

Organotypic 3D HepaRG Liver Model for Assessment of …

WebProduct Name: Cholyl-L-Lysyl-Fluorescein (CLF) Catalog number: 33288 Supplier: Medical Isotopes, Inc. 100 Bridge Street Pelham, NH 03076 USA Tel: +1-603-635-2255 … Webdrug hepatotoxicity, cholyl-l-lysyl-fluorescein, hepatobiliary transporters, DILI Bile flow is an essential biological process that facilitates the elimination of many drugs … the swan pub westgate on sea

Generation and metabolomic characterization of functional ductal ...

WebCholy-lysyl-fluorescein (CLF) is a fluorescein-labeled bile acid whose biological behavior closely resembles that of naturally occurring cholyl glycine. CLF is … WebCLF [Cholyl-Lys-Fluorescein] Catalog number: 36701 Unit size: 1 mg Product Details Storage Conditions Freeze (<-15 °C), Minimize light exposure Expiration Date 24 months … WebNov 4, 2024 · Plenty of NTCP inhibitors have been reported, although they are not transported by NTCP, e.g., cholyl-L-lysyl-fluorescein (CLF) is a good inhibitor but not a substrate . Peptidomimetic renin inhibitors propranolol, cyclosporin, oxysterols and progesterone, were found to be the potent inhibitors of NTCP [ 71 ]. the swan pub winwick

Determining functional activity of MRP2 and/or MRP3 efflux …

CLF [Cholyl-Lys-Fluorescein] AAT Bioquest

WebDirk de Waart is an academic researcher. The author has contributed to research in topic(s): Bile acid. The author has an hindex of 1, co-authored 2 publication(s) receiving 3 citation(s). WebNov 13, 2024 · Cholyl-l-lysyl-fluorescein is a synthetic fluorescent analog of the natural BA cholylglycine. It is used to visualize BA transport into the bile canaliculi (Mills et al., 1991). The kinetics of CLF excretion into rat bile resemble those of cholylglycine, which is excreted into the bile canaliculi. the swan pub yateWebCholyl-L-lysyl-fluorescein (CLF) is a fluorescent bile salt derivative that is being developed as an agent for determining in vivo liver function. However, the mechanisms of uptake and excretion... the swan pub west malling

"WebNov 22, 2024 · cholyl-L-lysyl-fluorescein CTNNB1 Catenin beta 1 DG diacylglycerol DNL de novo lipogenesis FA fatty acid FAHFA fatty acid esters of hydroxy fatty acids FPLC fast protein liquid chromatography-based sizeexclusion GTT glucose tolerance test HFD high fat diet HSC hepatic stellate cells IBA1 Ionized Calcium-Binding Adapter Molecule 1 IHC " - Cholyl-l-lysyl-fluorescein

Cholyl-l-lysyl-fluorescein

Maintenance of Primary Hepatocyte Functions In Vitro by …

WebJul 1, 2010 · Cholyl-l-lysyl-fluorescein (CLF) is a fluorescent bile salt derivative that is being developed as an agent for determining in vivo liver function. However, the mechanisms of uptake and excretion by hepatocytes have not been rigorously studied. We have directly assessed the transport capacity of various hepatobiliary transporters for CLF. WebCholyl-lysyl-fluorescein C51H63N3O11S CID 56626462 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological …

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WebCorning® Cholyl-Lysyl-Fluorescein (CLF), 1 mg Corning® Cholyl-Lysyl-Fluorescein (CLF), 1 mg by Corning Life Sciences Manufacturer Corning Life Sciences Model: … WebCholyl-L-lysyl-fluorescein (CLF) is a fluorescent bile salt derivative that is being developed as an agent for determining in vivo liver function. However, the …

WebAbstract: Background: Cholyl-lysyl-fluorescein (CLF) is a fluorescein-labelled bile acid whose biological behaviour closely resembles that of naturally occurring cholyl glycine. … WebApr 1, 2010 · Cholyl-L-lysyl-fluorescein (CLF) is a fluorescent bile salt derivative that is being developed as an agent for determining in vivo liver function. However, the …

WebOct 20, 2024 · Cholyl- l -lysyl-fluorescein (CLF) was purchased from BD Biosciences. Pitavastatin was obtained from LKT Laboratories. Other statins and bosentan were … WebNov 30, 1996 · Cholyl lysylfluorescein (CLF) and lithocholyl lysylfluoroscein (LLF) have properties similar to cholylglycine (CG) and glycolithocholate (GLC), respectively. In …

WebDec 1, 1991 · Cholyl-lys-F was synthesized employing equimolar amounts of cholyl-lys (sodium salt) and fluorescein isothiocyanate (FITC) in bicarbonate buffer (pH 9.5) over 16 h at room temperature (21 degrees C) with a yield of 70%. The fluorescent property of cholyl-lys-F was similar to fluorescein with a strong apple-green fluorescence.

WebNov 30, 1996 · Cholyl lysylfluorescein (CLF) and lithocholyl lysylfluoroscein (LLF) have properties similar to cholylglycine (CG) and glycolithocholate (GLC), respectively. In human and rat hepatocytes uptake... the swan pub warringtonWebCholyl-lys-fluorescein (CLF/cholyl-lys-F) is a bile acid (BA) analog, developed to investigate and determine in vivo liver functions. The compound is actually a fluorescein-labeled bile acid derivative with similar properties to … the swan pub wotton under edgeWebWith reference to Figure 32, Cholyl-L-Lysyl-Fluorescein (CLF) is a fluorescein-labelled bile acid whose biological behaviour closely resembles cholyl glycine, and is taken up by the OATP1B3... the swan queenWebApr 24, 2024 · Cholyl-lysyl-fluorescein (CLF) is a synthetic bile acid analog similar to cholyl glycine, and is taken up by hepatocytes in the liver and excreted into bile … the swan pub westgateWebDec 29, 2014 · Liver stem/progenitor cells, with the capacity to produce both mature hepatocytes and cholangiocytes, play essential roles in liver development and tissue regeneration after injury. 1 These cells could be a valuable renewable cell source for cell therapy to treat liver injury and degeneration. the swan queen balletWebSep 1, 2015 · Recently, imaging of biliary excretion of the fluorescent probe cholyl-L-lysyl-fluorescein (CLF) from rat hepatocytes was proposed to quantify drug-induced efflux transport inhibition (Barber et ... the swan queens squareWebQuantum yield. 0.79001, 0.952. CLF is a fluorescein-labeled bile acid analog that closely parallels the cellular binding and uptake properties of cholic acid derivatives. It is a divalent 'unipolar' anionic fluorescent monohydroxy bile salt analog with physical, biological and … the swan pub west wickham